After 15 years of development, the Guizhou Provincial Field Scientific Observation and Research Station for the Hongfeng Reservoir Ecosystem has been established as a comprehensive field observation and research platform integrating observation, research, demonstration, and service for high-altitude deep lake ecosystems. Based on long-term positioning monitoring of typical high-altitude deep lakes and reservoirs, the platform focuses on key scientific issues such as water resource development, water security, and water ecological restoration in the southwestern region. It has conducted in-depth analysis of the basic characteristics of high-altitude deep lake ecosystems, revealed the evolution characteristics and climate responses of these ecosystems, as well as the processes and mechanisms of biogenic element geochemical cycles. A series of key technologies for the protection and restoration of deep lakes and reservoirs have been developed, providing scientific and technological support for regional sustainable development.