The treatment of organic micropollutants has become a globally concerned environmental issue. Integrating the watershed characteristics and establishing an effective screening method to identify high-risk contaminants is key to achieving effective control of organic micropollutants. In this study, we focused on the shallow lake area （Lake Taihu）, and utilizing the concentration and toxicological data of contaminants in water and sediment, we developed a screening method for preferential control of organic micropollutants based on exposure risk and hazard risk indicators. Using the 2/3 cumulative rank method, 123 aqueous phase contaminants were scored, and 33 contaminants, including fluvalinate, permethrin and triphenyl phosphate etc, were identified as priority contaminants. Among them, 31 substances were determined through aqueous phase data assessment, while ethynylestradiol and perfluorododecanoic acid were added as supplementary targets following the incorporation of sediment exposure risk assessment data, which shows that exposure data of contaminants in sediments serves as an essential supplement to the scoring system for priority control frameworks. Among the selected 33 priority contaminants, 17 substances appear in various control lists of different countries, but 16 substances have not received sufficient attention. The uncertainty in this paper mainly stems from the lack of toxicity data for some contaminants and the acquisition of related thresholds, as well as insufficient timeliness and synchronization of monitoring data. It is recommended that future work should focus on establishing monitoring standards for organic micropollutants and improving toxicity data. This study can provide support for the effective control of emerging contaminants in river and lake regions nationwide.