Numerous studies have been conducted to investigate precipitation variation in the monsoon region of eastern China during the past millennium, however, most of them have mainly focused on the records from northern and central China, thus lacking of precipitation records from southern China. In the present study, we carried out multi-proxy analyses of lacustrine sediments from Yandang Mountain in Zhejiang Province of southern China, including total organic carbon (TOC), chromaticity, and grain size, to reconstruct past hydroclimatic changes since the Little Ice Age (LIA). The results show that: 1) during 1400-1600 AD, the lake expanded and the climate was relatively humid; 2) during 1600-1650 AD, precipitation decreased and the climate was drier; 3) during 1650-1750 AD, the climate became wetter; 4) during 1750-2000 AD, the climate remained relatively dry. It is noteworthy that during the period from 1500 to 1650 AD, humidity reconstruction from this study corresponds well with historical documents. Within uncertainties of the age calibrations, changes in our record are similar to those in the peat records from the Tianmu Mountain in Zhejiang Province, the Xianshan Mountain in Fujian Province, and the lacustrine records from Huguangyan Maar Lake, indicating the consistency of climate fluctuations in southeast China. In addition, the paleoclimate records of northern and southern regions in eastern China have the opposite trend of precipitation. It is suggested that, on the centennial scale, the precipitation variations in eastern China were characterized by the asynchronous pattern of moisture variations between northern and southern regions, i.e. “dry in northern China and wet in southern China” or “wet in northern China and dry in southern China”. The comparison with the Pacific Decadal Oscillation (PDO) shows that PDO plays an important role in the spatial precipitation characteristics of the “south-north” dipolar mode during the LIA in eastern China.