The Tibetan Plateau is one of the most important high altitude areas on the earth, which is sensitive to global changes. As the Asia Water Tower, the land surface water resources and their changes of the Tibetan Plateau have an important impact on the economic and social development of the plateau itself and its surrounding areas. However, under the condition of climate warming, there is less recognizance of the surface water facies shifting and their transformation for components of surface water resources, such as glaciers, lakes, rivers, precipitation and other water bodies. Lakes are the key link of the surface water facies shifting and water cycling on the Tibetan Plateau. Lake areas are sensitive to precipitation changes of the westerlies and the Indian monsoon dominant areas, but the responses of lake area and lake water storage are not always consistent in different regions and period. Lake water temperature has obvious response to climate warming, and the changes of lake water temperature and thermocline depth have obvious influence on the heat exchange of water-atmosphere, thus affecting the regional water cycle processes such as evaporation and precipitation. Due to the increase of lake water storage, the salinity of lakes in the Serling Co area has generally decreased since the 1970s. Based on the remote sensing inversion model constructed by the in-situ investigation of more than 60 lakes, it is found that the lake transparency has generally increased during 2000 and 2019. In terms of water balance monitoring in the big lakes of different supply types, the meteorological and hydrological factors affecting the lake change are quite different. In the current warm and humid climate state, lakes of the Tibet Plateau will continue to expand. In order to further understand the role of lake changes in the regional water cycle and climate change of the Tibetan Plateau, it is necessary to fully understand the variation of lake water storage and their continuous time series, to deeply understand the changes of lake physical and chemical parameters and the effect on heat exchange between lakes and atmosphere, and to obtain more comprehensive and continuous observation data from the great lake basins.