The consistency of proxies at different locations in a lake is of great importance to the reliability of regional climate reconstruction. At present, a single core in the central/deep lake was usually used to reconstruct the regional climate and environment change without verification. Here we compare the same proxy among the different core sediments from different locations of Lake Toson (37°04'-37°13'N, 96°50'-97°03'E, 2808 m a.s.l), which is located in Delingha, NE Tibetan Plateau. Core TSL15S1, TSL15S3, TSL15S7 and TSLG17 were recovered at the water depth of 1, 16.5, 16.5 and 25 m in Lake Toson, respectively. Based on the dating of ²¹⁰Pb and ¹³⁷Cs analyses, the changes of grain size, carbonate content and other proxies were compared and analyzed. The results show that the mean grain size is consistent at similar locations, while the grain size are quite different at distant locations within the lake. The grain size of sediments in the shallow water vary greatly in a short time scale, while the sedimentary environment in deep water is relatively stable, and the change is not obvious in the centurial. The variations of organic matter and carbonate content are consistent with each other, which indicates that carbonate may be affected by lake productivity. The organic matter content can reflect the size of lake productivity. The variations of carbonate content are consistent with the carbonate oxygen isotope in TSLC and the pollen A/C ratio of TL06, which was regarded as the substitute index of regional effective humidity. Therefore, the grain size in Lake Toson is reflecting the local sedimentary environment, and its relationship with the regional climate is not clear. Geochemical indexes are more reliable and are recommended for environment reconstructions in a well-mixed lake.