In Tibet, owing to the characteristics of fragile eco-environment, simple ecosystem structure, low productivity, slow fish growth, long period of resource complement, high fitness and dependence on the environment, the hydro-ecology of rivers and lakes is vulnerable to external factors. Especially, under the condition of alien fish invasion, hydropower facilities construction, overfishing, water environment deterioration, 35 fish species are confronting critically endangered, endangered, vulnerable, or extinction condition in the wild, which exceeding 20% of the total 162 fish species distributed in Tibetan Plateau. There are also 3 species confront endangered condition among 6 common Schizothorax fish species distributed in the middle reaches of Yarlung Zangbo River. Therefore, it is urgent to promote fishery resource conservation process in Tibet. Fortunately, supply-side structural reform and technological innovation will reinvigorate fishery resource conservation process. Through scientific guidance release behavior, specification and reinforcement fish stock enhancement behavior, accumulating and promoting breeding technology for native fish, closely focusing on hydro-ecology in Tibet, all these efforts will come to a new step for fishery resource conservation and promote targeted poverty alleviation process in Tibet.