Kunteyi Playa Lake, located in the northwest of Qaidam Basin, is an extremely large comprehensive salt deposit. The Great Salt Beach is the largest salt beach in the Kunteyi Playa Lake with underground brine deposit, poor hydrogeological conditions, and extremely low water content in the main seam, so it is difficult to exploit. Nuclear Magnetic Resonance (NMR) is a effective geophysical method currently used to detect groundwater directly. Comparing with the traditional geophysical methods, the NMR method is of higher resolution, more efficiency, more information and unique interpretation for hydrogeological investigations. In this paper, NMR sounding is used to study the space distribution characteristics of the underground brine. The NMR data were processed with the inversion, combined with geological and drilling data, and integrated with geological and geophysical interpretation for each measuring point. We find that in Kunteyi Playa Lake there are three brine aquifers exists from 0 to 130 m below the surface. The distribution of three brine aquifers is like funnel-shaped or approximate layer. The W₁ is latent brine formations, large permeability and coarse grain, with per unit volume of water of 0.4%-2.7%. The W₂ and W₃ are pressurized brine, low permeability and coarse grain, with per unit volume of water of 0.2%-1.1% and 0.1%-0.8% respectively. There existed two brine enrichment regions in the study area, the southwest centre of the exploration basin and the northeast basin. According to the distribution of brine and the structure in this area, we delimitate prospecting area of underground brine, the depositional centre of Great Salt Beach Synclinal, fault F1 to F8 and remote sensing fault F6 development areas in the north of the Great Salt Beach, cold-lake Structural belt. In dry salt lake area, the reliable detection depth of GMR system is 130 m. GMR systems can detect not only free water effectively, but also distribution of bound water to interpret the distribution rule of water-bearing salt minerals and aquiferous clay minerals.