From starting of diversions of lower reaches of Qarqan River, in 1989, there has been a lot of small lakes in the north side of the new riverbed, drives fluctuated changes of water area patterns in Tetima-Kanglayka lakes region. Since Emergency Ecological Water Transfusion(EEWT) project in lower reaches of Tarim River started in 2000, there are large water area began to reappear and expand in old Tetima lake bed, where there was dried up over than 30 years since a water caused by construction of Dashkol Reservoir. The lakes are already in stable position in Kanglayka region, but there are still big changes of water area in Tetima lake region, when the river diversions are finished in autumn 2002. In this paper, the water area change process and its change trend in Tetima-Kanglayka lakes region was analyzed in high temporal resolution based on a serial, 102 times, remotely sensed imageries which acquired from 1972 to 2012. A further study carried on integrated the result with runoff and transformed water amount data to find out dominant drivers of the changes. We concluded that water area landscape pattern changes was caused by interannual changes of Qarqan River run-off during 1970s till 2000, and has been controlled by the EEWT project in the lower reaches of the Tarim River till the end of research period.