Based on the continuous six-year MODIS data (from 2001 to 2006), changes of lakes in Maduo County were continuously monitored in recent years. The results showed that there were 35 lakes in 2006 more than that in 2001, and the lakes' area in 2006 was 56.59km² larger than that in 2001. The lake numbers and areas kept decreasing from 2001 to 2003 and were the least in 2003, but yearly increased from 2003 to 2006. Each lake presented the different change tendency, and was not consistent with general trend of lake changes of the county. The correlation coefficient between annual precipitation and the lakes' area was the most significant which indicated that the annual precipitation had important effect on the lakes' area of the county. Climatic elements had different effects on main lakes.