A first case study for the estimation of flood damages in the eastern Honghu flood diversion area is presented in this paper. The results display flood risk zones based on simulated estimation depths. They are the basis for an integrated model for flood damage estimation which combines a GIS-based hydrodynamic model for flood depth estimation with flow propagation and a GIS-, and RS-based unit flood damage model with different tangibles of flood damages. Hereby, the integrated flood damage estimation model proofs to be applicable at the Yangtze River.