Along with the highly speedy urbanization and industrialization in the cities around the Taihu Lake, such as Wuxi city, the modes of land use have changed greatly, especially the built up areas are sprawling, which has invaded the lakeshore ecological protection area, threatened the health of ecological system and aroused the worse water pollution. However, the feasible development regionalization of land use under ecological-economic approach is a useful path to zone the area for different intensity for the sake of spatial functional distribution assorting with need of the lake ecological protection, i.e. some area with large environmental capacity may be encouraged for industrialization and urbanization while the ecological sensitive areas restricted from exploitation. Then, the division of assessed units and chosen of the assessed elements have been discussed. After synthetic analysis of ecological protection value and economic development value, the region of Wuxi city, as a case, was divided into five types . preferential development, feasible development, limitary development, moderate conservation and absolute conservation. Finally, the policy of spatial governess was advanced for each type respectively.