Basing on the measurements for contents of TOC, TN, TP, Calcium and sulfide and AMS dating of sediment from Honghu Lake, we discussed the response of human activities in the lake sediment.The variations of TOC, TN are agreed with each other.They all appear as a remarkable peak value both on the top and bottom of the core, while flat in the midst.This indicates that the environmental change history of Honghu Lake can be divided into three distinct stages in recent 1500 a.TP generally ascend from past to present, but the extent of rise is not remarkable.This can be related to its complicated cycling mechanism in sediment.The profile of Calcium shows higher in the bottom lower in the top, its variation is complicated.The contents of sulfide on the top 15 cm is higher than the background, this possibly indicates the increase of mining intensity of iron ore and fossil fuel in the last century.